
宁波易赛腾生物科技有限公司独立研发的ECT快速直接转分化技术,打破了iPSC技术步骤繁琐、周期冗长、细胞胚龄化、无关键病理特征的主要局限。本公司特有的ECT技术快速制备的各种高纯度亚神经细胞(ECT-N)系列商业化产品,突破了相关药物研发领域无人源性年龄匹配、病理特征匹配的细胞模型的瓶颈,是神经退行性疾病机制研究及细胞筛药的理想模型。
2. Mertens, J. et al. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell 28, 1533-1548 e1536, (2021).
3. Mertens, J. et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell 17, (2015).
4. Liu, M. L., Zang, T. & Zhang, C. L. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep 14, 115-128, (2016).
5. Victor, M. B. et al. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci 21, 341-352, (2018).
6. Tang, Y., Liu, M. L., Zang, T. & Zhang, C. L. Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons. Front Mol Neurosci 10, 359, (2017).