基底前脑胆碱能神经元

Basal Forebrain Cholinergic Neuron

主要关联疾病:阿尔茨海默病、痴呆

基底前脑胆碱能神经元

基底前脑胆碱能神经元(BFCN), 是向大脑皮层、海马和杏仁核提供胆碱能神经支配的主要来源,在认知功能相关信息的处理中发挥关键作用,并参与注意力和记忆的调节回路。基底前脑胆碱能神经元发生退行性病变会使认知和记忆功能受到影响,从而导致阿尔茨海默病、痴呆等症状。
BFCN表达泛神经元标记物TUJ、MAP2和突触蛋白SYN1,常用的亚型标记物包括NKX2.1、GBX1、ISL1、CHAT和TRKA等。

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Human Fetal Basal Forebrain Cholinergic Neuron

Human Fetal Basal Forebrain Cholinergic Neuron

胎儿

规格: 1x10^6 cells/vial

货号: BFCN001

Human Fetal Basal Forebrain Cholinergic Neuron

Human Fetal Basal Forebrain Cholinergic Neuron

胎儿

规格: 1x10^6 cells/vial

货号: BFCN002

Human Early Young Basal Forebrain Cholinergic Neuron

Human Early Young Basal Forebrain Cholinergic Neuron

新生儿

规格: 1x10^6 cells/vial

货号: BFCN101

Human Early Young Basal Forebrain Cholinergic Neuron

Human Early Young Basal Forebrain Cholinergic Neuron

2岁

规格: 1x10^6 cells/vial

货号: BFCN102

Human Early Young Basal Forebrain Cholinergic Neuron

Human Early Young Basal Forebrain Cholinergic Neuron

新生儿

规格: 1x10^6 cells/vial

货号: BFCN103

Human Adult Basal Forebrain Cholinergic Neuron

Human Adult Basal Forebrain Cholinergic Neuron

成人

规格: 1x10^6 cells/vial

货号: BFCN201

Human Adult Basal Forebrain Cholinergic Neuron

Human Adult Basal Forebrain Cholinergic Neuron

28岁

规格: 1x10^6 cells/vial

货号: BFCN202

Human Adult Basal Forebrain Cholinergic Neuron

Human Adult Basal Forebrain Cholinergic Neuron

29岁

规格: 1x10^6 cells/vial

货号: BFCN203

Human Adult Basal Forebrain Cholinergic Neuron

Human Adult Basal Forebrain Cholinergic Neuron

47岁

规格: 1x10^6 cells/vial

货号: BFCN401

Human Aging Basal Forebrain Cholinergic Neuron

Human Aging Basal Forebrain Cholinergic Neuron

66岁

规格: 1x10^6 cells/vial

货号: BFCN601

Human Aging Basal Forebrain Cholinergic Neuron

Human Aging Basal Forebrain Cholinergic Neuron

71岁

规格: 1x10^6 cells/vial

货号: BFCN602

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

47岁

规格: 1x10^6 cells/vial

货号: BFCNAD001

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

69岁

规格: 1x10^6 cells/vial

货号: BFCNAD002

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

56岁

规格: 1x10^6 cells/vial

货号: BFCNAD003

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

56岁

规格: 1x10^6 cells/vial

货号: BFCNAD004

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

53岁

规格: 1x10^6 cells/vial

货号: BFCNAD005

Human AD Basal Forebrain Cholinergic Neuron

Human AD Basal Forebrain Cholinergic Neuron

71岁

规格: 1x10^6 cells/vial

货号: BFCNAD006

BFCN Recovery Culture Kit

BFCN Recovery Culture Kit

规格: Kit

货号: ECT-BFCNCM01

ECT-基底前脑胆碱能神经元特征蛋白表达

MAP2+ BFCN101表达胆碱能神经元特征转录因子GBX1(比例尺=50 µm,下同)

TUJ1+ BFCN101表达胆碱能神经元特征转录因子ISL1

TUJ1+ BFCN101表达胆碱能神经元特征转录因子Nkx2.1

TUJ1+ BFCN101表达成熟神经元突触蛋白SYN1

TUJ1+ BFCN101表达胆碱能神经元受体蛋白TRKA

TUJ1+ BFCN101表达胆碱能神经元特征蛋白CHAT

BFCN101表达神经元特征蛋白TUJ1和MAP2

病理特征

正常老年人(66岁)BFCN601中p-Tau的水平较低 (比例尺=20 µm,下同)

AD患者(56岁)BFCNAD04中p-Tau的水平明显高于正常对照细胞

正常老年人(66岁)BFCN601中Aβ42的水平较低

AD患者(56岁)BFCNAD04中Aβ42的水平明显高于正常对照细胞